Science, methodology and scientific evidence
Quantum Lab® scientific activity is based on peer-reviewed research, documented experimental development and national and international academic collaboration.
This section organizes our research lines and scientific publications that support our methodological framework in cellular biotechnology.
Our Scientific Approach
We work in clinical biotechnology under a structured framework of three levels of evidence: in vitro studies, in vivo validation and early clinical signals.
Based on this scheme, we design protocols under explicit criteria of safety, eligibility and objective follow-up.
We do not extrapolate findings out of context or communicate benefits without verifiable scientific support.
Operational details are protected under clinical confidentiality, without affecting traceability and transparency of results.
Lines of Research
Biomaterials and Tissue Microenvironments
We develop and validate bioactive scaffolds and functionalized surfaces (PCL/PLGA, chitosan, 3D textiles and composites) that replicate extracellular matrix properties.
We evaluate cell adhesion, osteogenesis, angiogenesis and biocompatibility using in vitro and in vivo models prior to any clinical transition.
Immunometabolism and Standardized Phytoactives
We evaluate bioactive extracts with certified analytical purity and documented traceability, analyzing their impact on markers of oxidative stress, systemic inflammation and metabolic parameters.
Clinical integration is considered only when there is sufficient experimental support and its scope and limitations are communicated.
Biosensors, Bioimpedance and Precision Medicine
We apply electrical bioimpedance, QCM-D and gene expression panels to quantify biological processes and monitor response under objective criteria.
These tools complement, but do not replace, clinical judgment.
Cell Biology and Immune Modulation
We studied the interaction between progenitor cells and the immune environment, including macrophage dynamics and osteogenic pathways such as BMP-2 and RUNX2.
All exploration is performed under evaluation of biocompatibility, safety and functionality in preclinical models prior to any clinical application.
Immunogenetics and Compatibility
We analyze histocompatibility markers (HLA) and other immunogenetic determinants that guide decisions related to compatibility and eligibility. These analyses support the clinical strategy, but do not in themselves constitute a therapeutic indication.
Academic and Institutional Collaborations
We participate in joint projects with universities and research centers that allow us to validate methodologies in external environments, guarantee reproducibility and maintain independent review.
These collaborations strengthen transparency and ensure that each advance is developed under standards comparable to international academic research. Collaboration agreement in force with the National Autonomous University of Mexico (UNAM).
Scientific publications and evidence base
The publications included document methods, experimental results and preclinical validations developed by team members and academic collaborators. Not all publications directly evaluate interventions that are integrated into the clinical setting. Findings should not be extrapolated outside their methodological context.
Biomaterials and tissue microenvironments.
We design and validate bioactive scaffolds and functionalized surfaces (PCL/PLGA, chitosan, composites and 3D textiles) that act as microhabitats for tissue repair. This line integrates material synthesis, physicochemical characterization and biological evaluation (adhesion, osteogenesis, angiogenesis and biocompatibility), with peer-reviewed publications and objective performance metrics.
Publications
González-González AM, Cruz R, Rosales-Ibáñez R, Hernández-Sánchez F, Carrillo-Escalante HJ, Rodríguez-Martínez JJ, et al. In vitro and in vivo evaluation of PCL/PLGA scaffold for cartilage injuries. Polymers (Basel). 2023;15:2324. doi:10.3390/polym15102324
Reyna-Urrutia VA, Rosales-Ibáñez R, González-González AM, Estevez M, Rodríguez-Martínez JJ, González-Reyna MA. Biological activity of a chitosan-carboxymethylcellulose-zinc oxide scaffold for bone tissue engineering. J Biomater Appl. 2023;-. doi:10.1177/08853282231168239.
Navarro-Cerón A, Barceló-Santana FH, Vera-Graziano R, Rivera-Torres F, Jiménez-Ávila A, Rosales-Ibáñez R, et al. Bovine dentin collagen/PLA scaffolds for tooth tissue regeneration. Iranian Polymer Journal. 2023;—. doi:10.1007/s13726-023-01139-y
Reyna-Urrutia VA, Estevez M, González-González AM, Rosales-Ibáñez R. 3D scaffolds of caprolactone/chitosan/PVA/hydroxyapatite seeded with swine DPSCs. J Mater Sci Mater Med. 2022;33:81. doi:10.1007/s10856-022-06702-2
Cerecedo-Sáenz E, Hernández-Lazcano E, González-Bedolla MJ, Hernández-Ávila J, Rosales-Ibáñez R, Gutiérrez-Amador MP, et al. Potassium jarosite for arsenic removal in contaminated waters: preliminary study. Int J Environ Res Public Health. 2022;19(23):15912.
Serralde-Lealba JR, Cerecedo-Sáenz E, Hernández-Ávila J, Arenas-Flores A, Veloz-Rodríguez MA, Gutiérrez-Amador MP, et al. Doped potassium jarosite for bone tissue engineering. Metals (Basel). 2022;12(6):1052. doi:10.3390/met12061052
Rosales-Ibáñez R, Viera-Ruiz AE, Cauich-Rodríguez JV, Carrillo-Escalante HJ, González-González AM, Rodríguez-Martínez JJ, et al. Electrospun/3D-printed PCL bioactive scaffold for bone regeneration. Polymer Bulletin. 2022;-.
Reyna-Urrutia VA, González-González AM, Rosales-Ibáñez R, Estevez M, Rodríguez-Martínez JJ, González-Reyna MA. Scaffolds used in cleft palate regeneration: a review. Polymers (Basel). 2022;14(3):547.
Oliver-Urrutia C, Rosales-Ibáñez R, Flores-Merino MV, et al. Lyophilized polyvinylpyrrolidone hydrogel for human oral mucosal stem cell culture. Materials (Basel). 2021;14:227.
García Pérez A, González-Aragón Pineda AE, Rosales-Ibáñez R, et al. Association between sociodemographic factors and dental caries in Mexican schoolchildren. Medicine (Baltimore). 2021;100(25):e26435.
Marin-Tapia HA, Romero-Salazar L, Arteaga-Arcos JC, Rosales-Ibáñez R, Mayorga-Rojas M. Micro-mechanical properties of corneal scaffolds from decellularized bi-models. J Mech Behav Biomed Mater. 2021;119:104510. doi:10.1016/j.jmbbm.2021.104510.
Rosales-Ibáñez R, Cubo-Mateo N, Rodríguez-Navarrete A, González-González AM, Villamar-Duque TE, Flores-Sánchez LO, et al. Assessment of a PCL-3D printing-dental pulp stem cells for bone engineering: an in vitro study. Polymers (Basel). 2021;13(7):1154. doi:10.3390/polym13071154
Flores-Cedillo ML, Rosales-Ibáñez R, Martín-del-Campo-Fierro M, Reyes-Matute A, Cauich-Rodríguez JV, Oros-Méndez LA, et al. Evaluation of the osteoinductive potential of HDPSCs grown on MWCNTs/PCL membranes. Polymer Bulletin. 2021;—. doi:10.1007/s00289-021-03721-x
Martín-Pat GE, Rodríguez-Fuentes N, Cervantes-Uc JM, Rosales-Ibáñez R, Carrillo-Escalante HJ, Ku-Gonzalez AF, et al. Effect of iodine-doped polypyrrole plasma treatment on PGS scaffolds. J Biomater Appl. 2020;-. doi:10.1177/0885328220941466.
Valadez-González A, Rosales-Ibáñez R, Rodríguez-Navarrete A, Villamar-Duque TE, Cano-Brown J, Carrillo-Escalante HJ, et al. Tailoring surface properties of carbon nanofibers via oxidation and its influence on dental pulp stem cell viability of PCL/CNF composites. Polymer Bulletin. 2020;—. doi:10.1007/s00289-020-03127-1
González-Aragón Pineda AE, García Pérez A, Rosales-Ibáñez R, Stein-Gemora E. Relationship between normative need for orthodontic treatment and oral health in Mexican adolescents aged 13-15 years. Int J Environ Res Public Health. 2020;17(21):8107.
Martín-Del-Campo M, Rosales-Ibáñez R, Rojo L. Biomaterials for cleft lip and palate regeneration. Int J Mol Sci. 2019;20(9):-.
Martín-Del-Campo M, Rosales-Ibáñez R, Sampedro JG, Flores-Cedillo ML, Rojo L. Bone regeneration induced by strontium folate loaded biohybrid scaffolds. Molecules. 2019;24(9):-.
Oliver Urrutia C, Rosales-Ibáñez R, Domínguez García MV, Flores-Estrada J, Flores-Merino MV. Synthesis and evaluation of poly(acrylic acid)/polyvinylpyrrolidone interpenetrating network as a matrix for oral mucosal cells. J Biomater Appl. 2019;-.
Sánchez-Pech JC, Rosales-Ibanez R, Cauich-Rodriguez JV, Carrillo-Escalante HJ, Rodríguez-Navarrete A, Avila-Ortega A, et al. Design, synthesis, characterization, and cytotoxicity of PCL/PLGA scaffolds by plasma treatment in the presence of pyrrole for urethral tissue engineering. J Biomater Appl. 2019;34(6):840-850. doi:10.1177/0885328219882638
Aguilar-Pérez FJ, Vargas-Coronado RF, Cervantes-Uc JM, Cauich-Rodríguez JV, Rosales-Ibáñez R, Rodríguez-Ortiz JA, et al. Titanium-castor oil-based polyurethane composite foams for bone tissue engineering. J Biomater Sci Polym Ed. 2019;-.
Rodríguez-Méndez I, Fernández-Gutiérrez M, Rodríguez-Navarrete A, Rosales-Ibáñez R, Benito-Garzón L, Vázquez-Lasa B, et al. Bioactive Sr(II)/chitosan/poly(ε-caprolactone) scaffolds for craniofacial tissue regeneration: in vitro and in vivo behavior. Polymers (Basel). 2018;10(3):-.
Guzmán-Uribe D, Alvarado-Estrada KN, Pierdant-Pérez M, Torres-Álvarez B, Sánchez-Aguilar JM, Rosales-Ibáñez R. Oral mucosa: an alternative epidermic cell source to develop autologous dermal-epidermal substitutes from diabetic subjects. J Appl Oral Sci. 2017;25(2):186-195.
Beltrán-Partida E, Valdéz-Salas B, Moreno-Ulloa A, Escamilla A, Curiel MA, Rosales-Ibáñez R, et al. Improved in vitro angiogenic behavior in anodized titanium dioxide nanotubes. J Nanobiotechnology. 2017;15:10.
Martin-Del-Campo M, Rosales-Ibañez R, Alvarado K, Sampedro JG, Garcia-Sepulveda CA, Deb S, et al. Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce in vivo bone regeneration in critical sized defects. Biomater Sci. 2016;4(11):1596-1604.
Ortiz M, Rosales-Ibáñez R, Pozos-Guillén A, de Bien C, Toye D, Flores H, Grandfils C. Colonization of DPSCs on functionalized 3D textiles. J Biomed Mater Res B Appl Biomater. 2016;-.
Santurdes N, González-Gómez A, Martín-del-Campo-Fierro M, Rosales-Ibáñez R, Oros-Ovalle C, Vázquez-Lasa B, San Román J. Development of bioresorbable bilayer systems for application as affordable dressings. J Bioact Compat Polym. 2016;31(6):624-647.
Flores-Cedillo ML, Alvarado-Estrada KN, Pozos-Guillén AJ, Murguía-Ibarra JS, Vidal MA, Cervantes-Uc JM, Rosales-Ibáñez R, Cauich-Rodríguez JV. Multiwall carbon nanotubes/polycaprolactone scaffolds seeded with human dental pulp stem cells for bone tissue regeneration. J Mater Sci Mater Med. 2016;27(2):35.
Olvera-Farias RM, Cruz-Perez JR, Salinas-Gutierrez R, Guerrero-Diaz de Leon JA, Kouri-Flores JB, Rosales-Ibáñez R, et al. Unilateral impact of altered loading by changing teeth height on the TMJ fibrocartilage: disc and condyle of Wistar rats. Microscopy Research. 2016;4(2):-.
García Pérez A, Higuera Martínez G, Rosales-Ibáñez R, Hernández González AK, Jiménez Ávila A, Ledesma Soto Y, et al. Isolation, culture and characterization of bone marrow stem cells from New Zealand breed rabbit femur. National indexed journal. 2018;30:-.
Oliver Urrutia C, Rosales-Ibáñez R, Flores-Merino MV, et al. Synthesis and evaluation of poly(acrylic acid)/polyvinylpyrrolidone IPN as a matrix for oral mucosal cells. J Biomater Appl. 2019;-.
Immunometabolism and bioactives
We study standardized bioactive compounds (e.g. Sechium extracts and dairy derivatives such as sodium caseinate) and their relationship with oxidative stress, inflammation, telomere dynamics and metabolic control. This axis combines in vitro, in vivo and early clinical trials to understand how these agents modulate immunometabolic pathways and contribute to more stable biological microenvironments.
Publications
Aguiñiga I, Meléndez-Ibarra FM, Ledesma-Martínez E, Weiss-Steider B, Fajardo-Orduna GR, Rangel-Corona R, Santiago-Osorio E. Improved survival of leukemic mice treated with sodium caseinate in combination with daunorubicin without toxicity. J Oncol. 2021;2021:6635650. doi:10.1155/2021/6635650. doi:10.1155/2021/6635650.
Rodríguez-Solano L, Aguiñiga I, López-Ortiz M, Tiburcio R, Luviano A, Regla I, Castillo I. Copper complexes derived from bis(2-methylbenzimidazolyl)amines and their antineoplastic activity. Eur J Inorg Chem. 2011;23:3454-3460. doi:10.1002/ejic.201100301
Ramos-Mandujano G, Weiss-Steider B, Melo B, Córdova Y, Ledesma E, Bustos S, Silvestre O, Aguiñiga I, et al. Alpha, beta and kappa caseins inhibit proliferation of 32D cl3 and WEHI-3 myeloid cell lines and exhibit different differentiation properties. Immunobiology. 2008;213:133–141. doi:10.1016/j.imbio.2007.07.004
Santiago-Osorio E, Mora L, Bautista M, Montesinos J, Martínez I, Ramos G, Aguiñiga I, et al. Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils. Immunobiology. 2010;215:332–339. doi:10.1016/j.imbio.2009.03.003
Domínguez-Meléndez V, Silvestre-Santana O, Moreno-Fierros L, Aguiñiga I, et al. Sodium caseinate induces mouse granulopoiesis. Inflamm Res. 2012;61(4):367-373. doi:10.1007/s00011-011-0421-7.
Ledesma-Martínez E, Pérez-Cordero C, Córdova-Galaviz Y, Sánchez-Téllez G, Huerta-Yépez S, Aguiñiga I, et al. Casein induces apoptosis of WEHI-3 leukaemic cells and increased survival in a leukaemic mouse model. Oncol Lett. 2012;4(3):461-466. doi:10.3892/ol.2012.758
Luviano A, Aguiñiga I, Demare P, Tiburcio R, Ledesma-Martínez E, Santiago-Osorio E, Regla I. Antineoplastic activity of rinvanil and phenylacetylrinvanil in leukemia cell lines. Oncol Lett. 2014;7(5):1651-1656. doi:10.3892/ol.2014.1958
Córdova-Galaviz Y, Ledesma-Martínez E, Aguiñiga I, Soldevila-Melgarejo G, Soto-García I, Weiss-Steider B, Santiago-Osorio E. Sodium caseinate induces increased survival in leukaemic mouse J774 model. In Vivo. 2014;28(5):819-825.
Aguiñiga I, Soto-Hernández M, Cadena-Íñiguez J, Ruíz-Posadas L, Cadena-Zamudio J, González-Ugarte A, Weiss-Steider B, Santiago-Osorio E. Fruit extract from a Sechium edule hybrid induces apoptosis in leukemic cell lines but not in normal cells. Nutr Cancer. 2015;67(2):250–257. doi:10.1080/01635581.2015.989370
Castillo I, Suwalsky M, Gallardo M, Troncoso V, Sánchez-Eguía B, Santiago-Osorio E, Aguiñiga-Sánchez I, González-Ugarte A. Structural and functional effects of benzimidazole/thiol-copper complexes with antitumor activity on cell membranes and molecular models. J Inorg Biochem. 2016;156:98–104. doi:10.1016/j.jinorgbio.2015.12.022
Domínguez-Meléndez V, Aguiñiga I, Moreno-Fierros L, Torres B, Osorio E. Sodium caseinate increases the number of B lymphocytes in mouse. Rev Biomed. 2017;37(4):571-576. doi:10.7705/biomedica.v37i4.3604.
Aguiñiga I, Cadena-Íñiguez J, Santiago-Osorio E, Gómez-García G, Mendoza-Núñez VM, Rosado-Pérez J, Ruiz-Ramos M, Ledesma-Martínez E, Delgado-Bordonave AJ, Cisneros-Solano VM, Soto-Hernández RM. Chemical analysis and in vitro and in vivo toxicity of methanolic extract of Sechium edule var. nigrum spinosum fruit. Pharm Biol. 2017;55(1):1638-1645. doi:10.1080/13880209.2017.1316746
Salazar-Aguilar S, Ruiz-Posadas L, Cadena-Íñiguez J, Soto-Hernández M, Santiago-Osorio E, Aguiñiga I, et al. Sechium edule (Jacq.) Swartz, a new cultivar with antiproliferative potential in a human cervical cancer HeLa cell line. Nutrients. 2017;9(8):798. doi:10.3390/nu9080798.
Suwalsky M, Castillo I, Sánchez-Eguía B, Gallardo M, Dukes N, Santiago-Osorio E, Aguiñiga I, Rivera-Martínez A. In vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes. J Inorg Biochem. 2018;178:87–93. doi:10.1016/j.jinorgbio.2017.10.009
Rosado-Pérez J, Aguiñiga I, Arista-Ugalde TL, Santiago-Osorio E, Mendoza-Núñez VM. Biological importance of oxidative stress, effects of fruits as edible natural antioxidants. Curr Pharm Des. 2018;24(40):4807-4824. doi:10.2174/1381612824666190114164758.
Weiss-Steider B, Córdova Y, Aguiñiga I, Ledesma-Martínez E, Domínguez-Meléndez V, Santiago-Osorio E. Sodium caseinate and α-casein inhibit proliferation of the mouse myeloid cell line 32D cl3 via TNF-α. Biomedica. 2019;39(3). doi:10.7705/biomedica.v39i3.4094
Rosado-Pérez J, Aguiñiga I, Santiago-Osorio E, Mendoza-Núñez VM. Effect of Sechium edule var. nigrum spinosum (Chayote) on oxidative stress and proinflammatory markers in older adults with metabolic syndrome: An exploratory study. Antioxidants. 2019;8(5):146. doi:10.3390/antiox8050146
Ledesma-Martinez E, Aguiñiga I, Weiss-Steider B, Rivera-Martinez AR, Santiago-Osorio E. Casein and casein-derived peptides as antileukemic agents. J Oncol. 2019;2019:8150967. doi:10.1155/2019/8150967.
Gavia-García G, Rosado-Pérez J, Aguiñiga I, Santiago-Osorio E, Mendoza-Núñez VM. Effect of Sechium edule var. nigrum spinosum on telomerase levels and antioxidant capacity in older adults with metabolic syndrome. Antioxidants. 2020;9(7):634. doi:10.3390/antiox9070634.
Aguiñiga I, Soto-Hernández M, Cadena-Íñiguez J, Suwalsky M, Colina JR, Castillo I, Santiago-Osorio E. Phytochemical analysis and antioxidant and anti-inflammatory capacity of Sechium híbrido fruit extracts. Molecules. 2020;25(20):4637. doi:10.3390/molecules25204637
Gavia-García G, Rosado-Pérez J, Arista-Ugalde TL, Aguiñiga I, Santiago-Osorio E, Mendoza-Núñez VM. Telomere length and oxidative stress and their relationship with metabolic syndrome components in aging. Biology. 2021;10(4):253. doi:10.3390/biology10040253.
Fajardo-Orduna GR, Ledesma-Martínez E, Aguiñiga I, Mora-García ML, Weiss-Steider B, Santiago-Osorio E. Chemoresistance pathway inhibitors in combination with Ara-C to overcome multidrug resistance in AML: A mini-review. Int J Mol Sci. 2021;22:4955. doi:10.3390/ijms22094955.
Salazar-Aguilar S, Ruiz-Posadas L, Cadena-Íñiguez J, Soto-Hernández M, Santiago-Osorio E, Aguiñiga I, et al. Microencapsulation of an extract of Sechium edule (Jacq.) Sw. with antineoplastic activity. Appl Sci. 2021;12:-.
Cadena-Íñiguez J, Aguiñiga I, Uriostegui-Arias MT, Santiago-Osorio E, Ruiz-Posadas L, Soto-Hernández M. Antiproliferative effect of Sechium edule cv. Madre Negra on breast cancer in vitro. Separations. 2022;9(9):230. doi:10.3390/separations9090230.
Delgado-Tiburcio EE, Cadena-Íñiguez J, Santiago-Osorio E, Ruiz-Posadas L, Castillo-Juárez I, Aguiñiga I, Soto-Hernández M. Pharmacokinetics and biological activity of cucurbitacins. Pharmaceutica. 2022;15(11):1325. doi:10.3390/ph15111325
Arista-Ugalde TL, Santiago-Osorio E, Monroy-García A, Rosado-Pérez J, Aguiñiga I, Cadena-Íñiguez J, Mendoza-Núñez VM. Antioxidant and anti-inflammatory effect of Sechium edule var. nigrum spinosum powder concentrate consumption in Mexican older adults with metabolic syndrome. Antioxidants. 2022;11(6):1076. doi:10.3390/antiox11061076. doi:10.3390/antiox11061076
Aguiñiga I, Ledesma-Martínez E, Lara-Castañeda JL, Meléndez-Ibarra FM, Weiss-Steider B, Soto-Cruz I, Santiago-Osorio E. Sodium caseinate in combination with daunorubicin or cytarabine improves survival of mice with long-established leukemia. Cancer Diagn Progn. 2022;2(4):496-502. doi:10.21873/cdp.10133.
Rivera-Martínez AR, Aguiñiga I, Cadena-Íñiguez J, Soto-Cruz I, Monroy-García A, Gómez-García G, Santiago-Osorio E. Fruit extract of Sechium chinantlense induces apoptosis in the human cervical cancer cell line HeLa. Nutrients. 2023;15(3):667. doi:10.3390/nu15030667.
Hernández-Álvarez D, Rosado-Pérez J, Gavia-García G, Arista-Ugalde TL, Aguiñiga I, Santiago-Osorio E, Mendoza-Núñez VM. Aging, physical exercise, telomeres and sarcopenia: A narrative review. Biomedicine. 2023;11(2):598. doi:10.3390/biomedicines11020598
Gavia-García G, Rosado-Pérez J, Arista-Ugalde TL, Aguiñiga I, Santiago-Osorio E, Mendoza-Núñez VM. Sechium edule consumption has antioxidant effect and prevents telomere attrition in older adults with metabolic syndrome. Redox Rep. 2023;28(1):2207323. doi:10.1080/13510002.2023.2207323
Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Dental pulp-derived mesenchymal stem cells: a review. Stem Cells Int. 2016;2016:4709572. doi:10.1155/2016/4709572.
Fajardo-Orduna G, Mayani H, Castro-Manrreza M, Flores-Figueroa E, Flores-Guzmán P, Arriaga-Pizano L, Santiago-Osorio E, Legorreta-Haquet M. Bone marrow mesenchymal stromal cells from clinical scale culture: in vitro evaluation of their differentiation, hematopoietic support, and immunosuppressive capacities. Stem Cells Dev. 2016;25(17):1299-1310. doi:10.1089/scd.2016.0071.
Hernández-Monjaraz B, Santiago-Osorio E, Monroy-García A, Ledesma-Martínez E, Mendoza-Núñez VM. Mesenchymal stem cells of dental origin to induce tissue regeneration in periodontitis: A mini-review. Int J Mol Sci. 2018;19(4):944. doi:10.3390/ijms19040944. doi:10.3390/ijms19040944.
Mendoza-Núñez VM, Arista-Ugalde TL, Rosado-Pérez J, Ruiz-Ramos M, Santiago-Osorio E. Hypoglycemic and antioxidant effect of Tai chi exercise training in older adults with metabolic syndrome. Clin Interv Aging. 2018;13:523. doi:10.2147/CIA.S157584
Hernández-Monjaraz B, Santiago-Osorio E, Ledesma-Martínez E, Alcauter-Zavala A, Mendoza-Núñez VM. Recovery of a periodontally compromised tooth by allogeneic grafting of dental pulp mesenchymal stem cells: a case report. J Int Med Res. 2018;46(7):2983-2993. doi:10.1177/0300060518773244
Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E. Mesenchymal stem cells for periodontal tissue regeneration in elderly patients. J Gerontol A Biol Sci Med Sci. 2019;74(9):1351-1358. doi:10.1093/gerona/gly227.
Mendoza-Núñez VM, García-Martínez BI, Rosado-Pérez J, Santiago-Osorio E, Pedraza-Chaverri J, Hernández-Abad VJ. Effect of supplementation with 600 mg of alpha-lipoic acid on oxidative stress, inflammation and RAGE in older adults with type 2 diabetes mellitus. Oxid Med Cell Longev. 2019;2019:3276958. doi:10.1155/2019/3276958
Hernández-Monjaraz B, Santiago-Osorio E, Ledesma-Martínez E, Aguiñiga-Sánchez I, Sosa-Hernández NA, Mendoza-Núñez VM. Dental pulp mesenchymal stem cells as a treatment for periodontal disease in older adults. Stem Cells Int. 2020;2020:8890873. doi:10.1155/2020/8890873. doi:10.1155/2020/8890873
García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VM. Hypoglycemic effect of resveratrol: a systematic review and meta-analysis. Antioxidants. 2021;10(1):69. doi:10.3390/antiox10010069.
García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VM. Influence of age and dose on the effect of resveratrol for glycemic control in type 2 diabetes mellitus: systematic review and meta-analysis. Molecules. 2022;27:5232. doi:10.3390/molecules27165232
Osorio ES, Ramirez-Padilla MG, Medina VM, Cadena JI, Hernandez MH, Rosado JP, Romero LE, Weiss SB, Gavia GG, Arista TL, Cruz VM, Aguiñiga-Sanchez I. Hepatoprotective effect of the Sechium HD-Victor hybrid extract in a mouse model of carbon tetrachloride-induced liver damage. Biomed Pharmacother. 2025;183:117831. doi:10.1016/j.biopha.2025.117831.
Biosensors, bioimpedance and precision medicine
We apply electrical and molecular measurement technologies (bioimpedance, QCM-D, gene panels and gene expression) to quantify biological processes such as inflammation and oxidative stress and to monitor responses to interventions. This axis connects instrumentation, signal analysis and early clinical validation in areas such as diabetes, infections, infertility and neurodegeneration.
Publications
Arias-González L, Cruz-Ramos JA, Pérez-Vielma NM, Munguía-Cervantes JE, Hernández-Sánchez E, Rojas López M, Gómez-López M. Correlation of EBIS versus total DNA concentration and purity in breast cancer samples. J Phys Conf Ser. 2025;3014:012011.
Cabrera Catalán B, Cleva Villanueva G, Pérez-Vielma NM, Lara Padilla E, Romero López E, Herrera López ME, Camberos Schiaffini DD, Gómez-López M. Use of bioimpedance as an early diagnostic tool in patients with diabetes. J Phys Conf Ser. 2025;3014:012003. doi:10.1088/1742-6596/3014/1/012003
Valencia-Gutiérrez MM, Gómez-López MPérez-Vielma NM, Lázaro-Aguilar P, Aguilera-Sosa VR. Clinical characteristics and cytokine gene expression in post-COVID-19 syndrome. Rev Med Inst Mex Seguro Soc. 2025;63(1):e6501.
Pérez-Vielma NM, Gómez-López MMartínez-Godínez MA, Luna-Torres AL, Domínguez-López A, Miliar-García Á. Candida variety in the oral cavity of Mexican subjects with type 2 diabetes mellitus and TLR2 gene expression. Clin Pract. 2024;14:417-425. doi:10.3390/clinpract14020031.
Pérez-Vielma NM, Valencia-Gutiérrez MM, Sánchez-Camacho JV, González-Hernández JE, Miliar-García Á, Ochoa C, Labovitz J, Gómez-López M. Hyperbaric oxygen therapy and oxidative stress/inflammation in diabetic foot ulcers: a preliminary study. Heliyon. 2024;10:e40586. doi:10.1016/j.heliyon.2024.e40586.
Sánchez-Camacho JV, Gómez-Chavarín M, Galindo-Solano N, Padilla-Cortés P, Maldonado-García JL, Pérez-Sánchez G, Pavón L, Ramírez-Santos J, Roldán R, Gómez-López MGutiérrez-Ospina G. Non-categorical analyses identify rotenone-induced ‘Parkinsonian’ rats benefiting from nano-emulsified punicic acid. Int J Mol Sci. 2024;25:12635. doi:10.3390/ijms252312635
González-Díaz CA, Suárez-Souto MA, Pérez-Soto E, Gómez-López MOGG1 Ser326Cys polymorphism in infertile men. Biomedicines. 2024;12:2286. doi:10.3390/biomedicines12102286
Morán-Guel E, Gómez-López M, Delgado-Aguirre HA. Risk factors for hospital-acquired infection in COVID-19. Med Crit. 2024;38(3):162-168. doi:10.35366/117778
Pérez-Vielma NM, Gómez-López MMaldonado-Vázquez J, Correa-Basurto J, Martínez-Godínez MA, Miliar-García Á. Interaction between the valpropropro peptide and the sod/cat minimal promoter region by QCM-D and docking. Anal Methods. 2023;-.
Padilla-García KL, Gómez-López MSánchez-Camacho JV, Andrade-Torres CM, Pérez-Vielma NM, González-Díaz CA. Bioimpedance spectra in RT-PCR end products: sensitivity threshold analysis. In: CNIB Proc. 2023:665-673.
Ángeles-Estrada L, Pérez-Soto E, Pérez-Vielma NM, Gómez-López MSánchez-Monroy V. Oxidative stress and genotoxicity in oral epithelial cells of orthodontic patients. Clin Oral Investig. 2023;-.
Carrizalez-Luna JE, Reséndiz-Albor AA, Arciniega-Martínez IM, Gómez-López MCampos-Rodríguez R, Pacheco-Yépez JC, Drago-Serrano ME. Effects of nicotinic modulation on intestinal IgA response. Biomed Rep. 2023;13:-.
Rojas-Ortega DA, Rojas-Hernández S, Sánchez-Mendoza ME, Gómez-López MSánchez-Camacho JV, Rosales-Cruz E, Carrasco-Yépez MM. Role of FcγRIII in BALB/c mice in primary amebic meningoencephalitis. Parasitol Res. 2023;-. doi:10.1007/s00436-023-07810-w.
Ames-Lastra G, Castillo-Salazar IA, Hernández-Nava A, Sánchez V, Gómez-López MPérez-Vielma N, González-Díaz CA. DNA biosensor by relative bioimpedance and gene amplification: preliminary results. J Phys Conf Ser. 2021;-.
Ames-Lastra G, Sánchez V, Sacristán-Rock E, Gómez-López MPérez-Vielma N, Castillo-Salazar IA, Hernández-Nava A, González-Díaz CA. Bioimpedance spectroscopy to detect label-free PCR products. J Phys Conf Ser. 2021;-.
Hernández A, Ames G, Sánchez V, Gómez-López MSánchez J, Pérez N, Castillo IA, González CA. Correlation between DNA concentration and electrical bioimpedance. J Phys Conf Ser. 2021;-.
Marín-Soto MD, Miliar-García Á, Gómez-López MGonzález-Mundo I, Aguilera-Sosa VR. Association between food craving and taste genes in people with obesity. Invest Clin. 2021;62(2):119-131. doi:10.22209/IC.v62n2a03
Sandoval-Valerio AK, Aguilera-Sosa VR, Miliar-García Á, Gómez-López MGarcía-García C, Leija-Alva G, Sánchez-Camacho JV, Pérez-Vielma NM. Modulation of catastrophic thinking, pain and inflammation in fibromyalgia. Invest Clin. 2021;62(2):140-158. doi:10.22209/IC.v62n2a05
González-Mundo I, Pérez-Vielma NM, Gómez-López MFleury A, Correa-Basurto J, Rosales-Hernández MC, Sixto-López Y, Martínez-Godínez MA, Domínguez-López A, Miliar-García Á. REST DNA methylation and antioxidant enzyme expression in Alzheimer's disease. Exp Gerontol. 2020;136:110951. doi:10.1016/j.exger.2020.110951.
Gómez-López MMiliar-García Á, Pérez-Vielma NM, Lara-Padilla E, González-Díaz CA. Electrical bioimpedance-based biomarker biosensor of inflammation. J Electr Bioimp. 2020;11:31-37. doi:10.2478/joeb-2020-0006.
Gómez-López MMiliar-García Á, Pérez-Vielma NM, Ames-Lastra G, Lara-Padilla E, Chávez KV, García AR, Delgado J, Cortés E, González-Díaz CA. NLRP3 bioimpedance biosensor. IFMBE Proc. 2019;75:1488-1493. doi:10.1007/978-3-030-30648-9_191.
Sandoval-Valerio AK, Pérez-Vielma NM, Miliar-García Á, Gómez-López MGarcía-García C, Aguilera-Sosa VR. Negative thoughts and stress associated with the 5HT1A receptor in women with fibromyalgia. Acta Invest Psychologica. 2020;10(3):—. doi:10.22201/fpsi.20074719e.2020.3.3619
Gómez-López MMiliar-García Á, Pérez-Vielma NM, Ames-Lastra G, Lara-Padilla E, Chávez KV, García AR, Delgado J, Cortés E, González-Díaz CA. NLRP3 bioimpedance biosensor (conference version). IFMBE Proc. 2019;75:-. doi:10.1007/978-3-030-30648-9_19.
Gómez-López M, et al. Complementary DNA biosensor based on electrical bioimpedance. COMIB/CNIB. 2017;—. doi:10.24254/CNIB.17.93
Gómez-Conde E, Díaz-Orea MA, Pimentel-Morales A, Cárdenas-Perea ME, Galicia-Zamalloa AL, Guerrero-González T, González-Barrios JA, Gómez-López MLara-Padilla E. MAP4/MAP6 expression in breast cancer cell lines. Int J Clin Exp Pathol. 2017;10(6):7017-7022.
Cell biology and immune modulation
We investigate how different stimuli-hormonal, nutraceutical and biomedical materials-regulate key cellular pathways (macrophages, oxidative stress, osteogenesis) and cell-material interactions. We combine in vitro assays, in vivo studies and expression analysis to identify markers of safety, viability and differentiation in human cells (e.g. MSCs), as well as immunomodulatory effects with translational potential.
Publications
Parra-Barrera A, et al. Successful creation of neoesophagus by tissue engineering in an animal model. Rev Mex Cir Pediatr. 2008;15(2).
Parra-Barrera A, et al. Autologous mesenchymal stem cells and autologous skin graft for chronic ulcer secondary to type 2 diabetes mellitus. Cir Cir. 2015;83(6).
Parra-Barrera A, et al. Inhibition of the Na+/H+ antiporter induces cell death in TF-1 erythroleukemia cells stimulated by stem cell factor. Cytokine. 2015;75:142-150.
Parra-Barrera A, et al. Internalization of titanium dioxide nanoparticles by glial cells occurs in short times and is mediated mainly by actin rearrangement-dependent endocytosis. Neurotoxicology. 2015;51:27-37.
Parra-Barrera A, et al. Effect of dehydroepiandrosterone on BMP2, SPARC and RUNX2 expression in human bone marrow mesenchymal stem cells. Rev Mex Ing Quim. 2016;15(1).
Parra-Barrera A, et al. Comparison between mesenchymal stem cells obtained from bone marrow, adipose tissue and Wharton's jelly based on ISCT criteria. Rev Mex Ing Biomed. 2017;38(1):280-287.
Parra-Barrera A, et al. Effect of H9C2 conditioned medium treated with dehydroepiandrosterone and exposed to damage on bone marrow MSC motility. Rev Mex Ing Biomed. 2017;38(1):256-263.
Parra-Barrera A, et al. Effect of dehydroepiandrosterone and triamcinolone acetonide on the 3T3-L1 cell line. Rev Mex Ing Biomed. 2017;38(1):288-296.
Parra-Barrera A, et al. How infectious agents play a role in childhood leukemia. Arch Med Res. 2017;48:305-315.
Palma-Lara I, Calzada-Mendoza CC, Mera-Jiménez E, Romero López E, Amaya-Espinoza JL, Parra-Barrera A, Gutiérrez-Iglesias G. Regenerative medicine for chronic ulcers: cutaneous application of Wharton's jelly MSCs. Rev Mex Ing Biomed. 2019;40(2):1-11.
Aguayo-Cerón KA, Morales-González JA, Gutiérrez-Iglesias G, Parra-Barrera A, Jiménez-Zamarripa CA, Ocharán-Hernández ME, Calzada-Mendoza CC. Regulatory effect of tibolone on macrophage anti-inflammatory activity. Rev Mex Ing Bioméd. 2019;40(3):1-10. doi:10.17488/RMIB.40.3.1.
Peralta-Vega AB, Parra-Barrera A, Ramos-Godínez MP, López-Marure R, Arellano-Galindo J, Gutiérrez-Iglesias G. Toxic effect of titanium dioxide nanoparticles on human mesenchymal stem cells. Mol Cell Toxicol. 2020;16:321–330. doi:10.1007/s13273-020-00084-8
Flores-Mejía R, Fragoso-Vázquez MJ, Pérez-Blas LG, Parra-Barrera A, Hernández-Castro SS, Estrada-Pérez AR, Rodríguez J, Lara-Padilla E, Ortiz-Morales A, Correa-Basurto J. Chemical characterization (LC-MS-ESI), cytotoxic activity and intracellular localization of PAMAM G4 in leukemic cells. Sci Rep. 2021;11:8210. doi:10.1038/s41598-021-87560-w
Aguayo-Cerón KA, Gutiérrez-Iglesias G, Parra-Barrera A, Ocharan-Hernández ME, Romero-Nava R, Jiménez-Zamarripa CA, Calzada-Mendoza CC. Antisclerotic effect of tibolone by reducing proinflammatory cytokine expression, ROS production and LDL-ox uptake in THP-1 macrophages. Steroids. 2021;167:108779.
Palma-Lara I, Calzada-Mendoza CC, Mera-Jiménez E, Romero López E, Amaya-Espinoza JL, Parra-Barrera A, Gutiérrez-Iglesias G. (-)-Epicatechin promotes bone regeneration by inducing BMP2, SPARC and RUNX2 expression in mesenchymal stem cells in vitro. J Med Food. 2025; [e-publication ahead of print]. doi:10.1089/jmf.2024.0256.
Immunogenetics and compatibility
We analyze histocompatibility markers (HLA) and other immunogenetic determinants to support safe decisions on compatibility, donor selection and eligibility criteria. This line links HLA typing, population registries and standardized technical documentation with clinical applications where the immune response is critical.
Publications
Magazine articles
Rangel R, et al. Macrolide-Clarithromycin Task-Force for the Treatment and Prophylaxis of COVID-19 as a Single Agent. Pharmacology and Pharmacy. 2020;11(6):131–142. doi:10.4236/pp.2020.116012
Other academic publications (proceedings, technical manual)
2. Rangel R, Alaez C, Berumen J, Gorodezky C. Involvement of HLA class I and class II loci in cervical cancer expression in Mexican-mestizo women in the context of human papillomavirus. Hum Immunol. 2001;62(Suppl 1):S83.
3. Flores H, Alaez C, Hernández M, Arroyo M, Rangel R, et al. Analysis of data from the Mexican registry of bone marrow donors (DONORMO). Hum Immunol. 2001;62(Suppl 1):S169.
4. Flores H, Alaez C, Rangel R, et al. HLA class I antigens and DRB1, DQA1 and DQB1 alleles in patients with chronic myeloid leukemia (CML) belonging to 150 families. Clinical Histocompatibility Workshop Visuals. 2002:85-86.
5. Pan American Health Organization; INDRE. Manual of serological and cellular histocompatibility procedures. 1999. 1999 (Institutional technical manual).
The publications listed here document methods and results; they do not all evaluate the same interventions that are integrated into the clinical setting. Findings should not be extrapolated out of context. For criteria and controls applicable to our processes.