Quantum Lab
DEVELOPING THE INTELLIGENT MEDICINE
Q-SUPPORT: Innovative Solutions for Optimal Health
Q-SUPPORT GUMS
Enhances periodontal health, reduces inflammation, and supports gingival tissue regeneration. Helps combat gingival recession and inflammation in patients with gum diseases.
Q-SUPPORT BONE
Stimulates bone regeneration, facilitating the growth of new bone tissue for improved structure and function. Ideal for restoring compromised bones.
Q-SUPPORT SYSTEMIC
Innovatively addresses chronic degenerative, autoimmune diseases, cancer, and other debilitating conditions impacting overall health.
Q-SUPPORT AESTHETICS
Enhances elastin, collagen production, treats scars, stretch marks, and improves hair health. Our precursor technology aids muscle definition.
Q-SUPPORT JOINT
Promotes joint health by fostering cartilage regeneration, alleviating pain, stiffness, and inflammation associated with joint disorders.
ABOUT US
Quantum Lab is a multidisciplinary team comprised of doctors, biologists, biochemists, and biophysicists with extensive experience and diverse skills. Our mission is to drive research and innovation in various branches of medicine and biological sciences by using cutting-edge technology to enhance medical treatments.
Quantum Lab Providers
Ernesto Romero
Founder of Quantum Lab and CEO of Krebs International, Immunotherapymx and Hemofenix in Mexico
As a pioneer in modern medical research, Dr. Romero has been at the forefront of stem cell and immunotherapy technology and patient care for over 20 years. In addition, his strong commitment to alternate healthcare options has contributed significantly to the growing field of immunotherapy in North America and Europe.
Raúl Rosales Ibáñez
Ph.D. of Science in Tissue Engineering in Medicine and Dentistry
Supervised more than 11 undergraduate theses, 11 master’s theses, and 12 doctoral theses, and has been an examiner, panel member, or jury in more than 25 theses at various academic levels. Additionally, he is in charge of international donations at institutions such as CONACyT and various programs of the UNAM, including PAPIIT, PAPIME, and PAPCA. Currently, he leads the Laboratory of Tissue Engineering and Translational Medicine at the UNAM Dental Clinic, standing out for his commitment to education and advanced research in medicine.
Alberto Parra Barrera
Ph.D. in Chemical-Biological Sciences
A distinguished professional with a Doctorate in Chemical-Biological Sciences, deeply involved in research and teaching in their field. Essential in various projects on regenerative medicine and leukemia, they have led significant research since 2017. Their scientific contributions are evident in numerous publications, spanning from tissue engineering to mesenchymal stem cell studies. They have also significantly contributed to academic training as a co-director of master’s theses. Recognized with prestigious roles, including a candidacy in the National System of Researchers (SNI) by CONACYT and a professorship at the Higher School of Medicine, they exemplify dedication to education and advanced research in their specialty.
Jorge Cadena Íñiguez
Ph.D. in Botany
Is a leading researcher and academic in botany and agronomy, with a notable contribution to scientific knowledge and sustainable agricultural development. Throughout his career, he has published over 109 scientific articles and books, obtained 6 process patents, and registered 19 plant varieties. He is renowned for his leadership in technological innovations, with 17 developments, and his crucial role in training 49 postgraduate talents. He has driven the creation of 87 rural enterprises and has been recognized with academic distinctions and awards, including the Miguel Alemán Valdés Prize for innovation. Dr. Cadena has also made significant contributions to agricultural science and practice through his involvement in important international projects, standing out for his work in biodiversity conservation and agricultural resource management.
Aguiñiga Sánchez Itzen
Ph.D. in Biological Sciences
He began his academic career in Biology at the Faculty of Higher Studies “Zaragoza”, UNAM, where he completed his undergraduate studies, presenting a thesis on the effect of sodium caseinate on the proliferation and differentiation of myeloid cell lines. He continued with a Master of Science at the Postgraduate College, researching the antileukemic potential of Sechium spp. genotypes, and later expanded his specialization with a Master in Nutrition and Food-Drug Interactions at the University of Barcelona, focusing his work on the relationship between nutrition and medicine. His doctoral training began with a Doctorate in Sciences at the Postgraduate College, where he was recognized for his research on the antitumor effect of Sechium P. Browne, followed by a Doctorate in Education at UTEL University, demonstrating an exceptional commitment to scientific research and education.
Edelmiro Santiago Osorio
Ph.D. in Biological Sciences
He began his academic career in Biology at the National School of Professional Studies “Zaragoza”, UNAM, presenting a thesis on the effect of lymphocytes and monocytes on cell proliferation. He furthered his education with a Master’s in Science (Biology) at the Faculty of Sciences, UNAM, expanding his specialization in the field. His education progressed with a Doctorate in Science (Biology) at the same institution, focusing on the study of free radicals in the cellular defense system and DNA damage. His doctoral research explored the induction of Fc receptor expression by Interleukin 1 in normal and leukemic myeloid cells, establishing his profile as a distinguished scientist in biology.
Arely Montserrat González
Ph.D. of Science in Infectomics and Molecular Pathogenesis
Dental health professional with advanced training, including a Bachelor’s degree in Dental Surgery and a Doctor of Science in Infectomics and Molecular Pathogenesis. Dedicated to the research and application of advanced techniques in cellular and molecular biology, with specialization in tissue engineering and mesenchymal stem cell differentiation. University education and advisory roles in research projects have significantly contributed to scientific advancement and institutional development, promoting best practices in oral health.
Lidia Cerda Aguilar
Ph.D. in Human Genetics
Lidia Cerda Aguilar completed her academic training at the University of Guadalajara, where she earned her Bachelor’s degree in Biology between 1993 and 1998. She continued her studies at the same institution, completing a Master’s in Human Genetics from 1998 to 2000. Her education concluded with a Ph.D. in Human Genetics, also at the University of Guadalajara, from 2000 to 2002.
María Guadalupe Ramírez Padilla
Bachelor of Science in Biology
Graduated from the Faculty of Higher Studies Zaragoza, UNAM, with a Bachelor’s degree in Sciences and recognition for academic excellence in inter-school competitions.
Specialized in biology and in vitro culture management, with practical experience in sugarcane plant production and a proven track record of technical skills in hematopoiesis and leukemia, including the handling of various cell lines and laboratory animals.
Co-author of an international scientific publication contributing to the understanding of leukemia treatment, highlighting a commitment to applied research and the advancement of knowledge in the oncology field.
Sac-Nicté García Gervasio
Bachelor of Science in Biology
Biologist with specialization in the field of hematopoiesis and leukemia, graduated from the Faculty of Higher Studies Zaragoza, UNAM. Strong experience in animal facilities, handling of recognized cell lines, and advanced laboratory techniques such as flow cytometry, hematology, and PCR.
Notable for innovation in the encapsulation of natural supplements and preparation of tinctures, with teaching skills for group management. Author of published research on the feasibility of non-toxic oncological treatments and significant contributions to national and international conferences, reflecting a career dedicated to translational research and scientific education.
Carlos Céspedes Hernández
Bachelor’s degree in Chemistry.
Graduated in Chemistry from the Pontifical Catholic University of Chile. Experienced in applied research for the production of high-temperature or biological superconductors using elements with electronic configurations d10 s1, d8 s1, d9 s1. Industrial experience in the research and production of products with ionically solvated nanoparticle copper in structured water for topical and ingestible use.
Vicente Boscá Terol
Specialist in regenerative medicine.
Graduated in Medicine and Surgery from the Faculty of Medicine of Valencia, this professional holds a diploma in homeopathy from C.E.D.H. and has been a professor of homeopathy for 30 years in courses at faculties and colleges of doctors and pharmacists. He also has a master’s degree in Medicine and Aesthetic Surgery and is a neural and ozone therapist. Specializing in regenerative medicine, he has been an international professor in this field for the UCAM of Spain. Additionally, he is a co-founder of the international OTTO H. WARBURG Conferences for Spain and South America.
Amairany Rodríguez Navarrete
Molecular biomedicine
Dentist Surgeon graduate from the Faculty of Superior Studies Iztacala, UNAM, Master of Science in Molecular Medicine graduate from the ENMyH of IPN, Adjunct Professor in the Dentist Surgeon program at the Faculty of Superior Studies Iztacala, UNAM. Ph.D. candidate in Biotechnology at the ENMyH of IPN.
WHAT ARE stromal precursors?
They are cells with the ability to repair damaged tissues or organs, given their high capacity to differentiate into different cell lines capable of repairing injuries to the skin, bone, tendons/joints, muscle, heart, kidney, lung, and brain or used in aesthetics, such as anti-aging.
In addition to having an important role in the regeneration of organs and tissues, they are important for the treatment of autoimmune diseases, avoiding organ rejection in transplants of stromal precursors, hematopoietic cells, kidneys, liver, etc., and reducing graft-versus-host disease.
They have immunomodulatory functions, so they are excellent for the treatment of allergies, asthma, COVID-19, and/or acute or severe respiratory diseases.
They synthesize large amounts of growth factors/cytokines, as well as other bioactive factors that are contained in exosomes or microvesicles and function in a paracrine manner and have enormous therapeutic potential.
Mesenchymal stromal precursors support skeletogenic, angiogenic, anti-inflammatory, and immunomodulatory activities and thus can be used in cell therapies.
Stromal precursors express toll-like receptor 4, so that, in the presence of inflammatory stimuli, they immediately go to the inflammatory site (chemotaxis), expressing interferon regulatory transcription factors 1 (IRF1) and NFκB. IRF1 induce the synthesis of interferons by cells near the inflammatory focus and MSCs capture it to induce the expression of the enzyme indoleamine 2,3-dioxygenase (IDO1), this enzyme captures tryptophan from the medium and transforms it into cynurenine so the inflammatory cells (virgin or memory T and B lymphocytes and NK cells) so the proliferation of these cells is significantly reduced, reducing inflammation.
In an inflammatory process there are abundant amounts of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interferon gamma (IFNꙋ), which act synergistically in MSCs to synthesize immunosuppressive factors such as IL-4, IL-10 , CD274/PD-L1, IDO. There are other suppressor/inhibitor molecules that are expressed on the membrane, such as the non-classical molecule of the major histocompatibility complex class I, called HLA-G. Prostaglandin E2 (PGE2) is a constitutively produced molecule with inhibitory effects on peripheral blood mononuclear cells. In addition to improving paracrine signaling, these cytokines increase the expression of genes associated with programmed cell death or apoptosis. Interleukin 10 (IL-10), is synthesized by mesenchymal stromal precursors, which stimulates the proliferation of a population of regulatory T lymphocytes that in turn synthesize the anti-inflammatory cytokine transforming growth factor b (TGFβ) which further stimulate the proliferation of regulatory T cells.
Stromal precursors and Antigens
Stromal precursors express a set of surface antigens (must be positive) and the absence of others (must be negative). The antigens that must be expressed are: CD73, CD90 and CD105, while they must be negative for CD45, CD34 and HLA-DR. Thus, they must also express genes related to the “trocalidad” such as: nanog, c-myc, klf2.
The search for soluble factors secreted by stromal precursors that promote immunomodulation has intensified, thus multiple factors have been identified that limit immune cell responses, including transforming growth factor β (TGFβ), growth hormone (HGF), prostaglandin E2 (PGE2), interleukin-10 (IL-10), interleukin-1 (IL-1), receptor antagonist interleukin-6, human leukocyte antigen-G (HLA-G), leukocyte inhibitory factor (LIF), indoleamine-2, 3-dioxygenase (IDO), nitric oxide (NO), galectins-1 and -9 (GAL1 and GAL9), and TNFα-stimulated gene 6 (TSG-6).
Stromal precursors lack histocompatibility complex class II (MHC-II) molecules on their cell surface. However, they express class I molecules at low levels, so they are more susceptible to being eliminated by NK cells, which belong to the innate response and sense the levels of MHC-I on the membrane of target cells through the death inhibitory receptors (KIR) and death activating receptors (KAR). However, it has been shown that NK cells do not kill stromal precursors due to other mechanisms that suppress them, such as IDO, PGE2, TGFβ, regulatory T lymphocytes, etc.